Abstract
This study investigated the analgesic and anti-inflammatory effects of Crinum asiaticum (Amaryllidaceae) leaf ethanolic extract. Analgesic effect was investigated in acetic acid induced writhing model and formalin induced licking model in swiss albino mice. Anti-inflammatory effect was conducted in carrageenan-induced paw edema model of albino rat. Data were analyzed by one-way analysis of variance (ANOVA) followed by post hoc multiple comparison test. In analgesic study, C. asiaticumextract inhibited 42.34±3.20% of acetic acid induced pain at higher dose of 2.0 g/kg body weight. The effect was statistically significant (p<0.001) compared to the positive control, diclofenac sodium (10 mg/kg). The extract reduced the formalin induced pain22.60±1.39% in early phase and 27.11±0.87% in late phase at the same dose of 2.0 g/kg and the reductions were significant (p<0.01) compared to the positive control morphine (0.5 mg/kg). In a time-dependent inhibition of carrageenan-induced paw edema model, the extract promoted the inhibitions of paw edema 51.60±2.50% at the 1st h and 40.80±0.52% at the 4th h of administration. These inhibitions were also significant (p<0.01) in comparison to those promoted by diclofenac sodium. No mortality was observed in acute toxicity test. The study concludes that C. asiaticumleaf extract has potential analgesic and anti-inflammatory effects to be recorded as plant-derived complementary medicine. Key words: Crinum asiaticum, anti-inflammatory, analgesic, Carrageenan, formalin.
Highlights
Important pharmacological properties, convenience to users, economic viability and low toxicity of plant-derived medicines from various plants have notably attracted and increased the interest of scientists since last couple of decades (Prashant et al, 2008)
Analgesic effect was investigated in acetic acid induced writhing model and formalin induced licking model in swiss albino mice
The study concludes that C. asiaticum leaf extract has potential analgesic and anti-inflammatory effects to be recorded as plant-derived complementary medicine
Summary
Convenience to users, economic viability and low toxicity of plant-derived medicines from various plants have notably attracted and increased the interest of scientists since last couple of decades (Prashant et al, 2008) This revived interest to plant-derived medicines is mainly due to the current widespread perception that green medicine is safe and dependable than the costly synthetic drugs most of which have adverse effects (Jigna and Sumitra, 2006). In Southeast Asian countries, C. asiaticum has a considerable medicinal reputation as a potent folk medicine in the treatment of injury and inflamed joints (Burkill, 1966). In early times, it had been used in Indonesia and in Malay Peninsula as an antidote for wounds from poisoned arrows. Anti-inflammatory effect of C. asiaticum by the inhibition of inducible nitric oxide
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