Abstract
English
Highlights
Diabetic neuropathy is one of the most common diabetic complications, characterized by neuropathic pain that occurs spontaneously (Arora and Singh, 2013), with approximately 50% of diabetic patients to suffer from pain and hyperalgesia
Increasing evidence indicated that hyperglycemia played a key role in the development and progression of diabetic neuropathy (Singh et al, 2014)
Hyperglycemia induces oxidative stress to generate reactive oxygen species and reactive nitrogen species in diabetic neurons resulting in neuronal damage and dysfunction (Vincent et al, 2005)
Summary
Diabetic neuropathy is one of the most common diabetic complications, characterized by neuropathic pain that occurs spontaneously (Arora and Singh, 2013), with approximately 50% of diabetic patients to suffer from pain and hyperalgesia (an increased level of glucose in the blood). Neuropathic pain is mostly associated with longtime exposure to high glucose, hyperglycemia is considered as a major factor of tissue damage (Afrazi et al, 2014). The mechanisms of diabetic neuropathy are not completely known. Some evidence indicated that hyperglycemia induced atherosclerosis, contributing to insufficiency of blood flow to neuronal cells (Green et al, 2014). Not much is known about the direct toxic effect of high glucose levels on neuronal cells. The effect of high glucose on cell viability was determined on high-differentiated PC12 cells as a model of neuronal cells
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