Abstract
English
Highlights
IFNs are a family of natural multifunctional glycoproteins with a multitude of antitumor effects including inhibition of cell proliferation, induction of cell differentiation, upregulation of class I major histocompatibility complex antigens, inhibition of angiogenesis, and establishment of a T-helper 1 (Th1) type response [1, 2].IFN- sensitizes human malignant glioma cells to CD95Linduced apoptosis [3] down-regulates the expression of the proangiogenic molecules, such as basic fibroblast growth factor, IL-8, and matrix metalloproteinase (MMP)-2 and -9 and inhibits the motility of vascular endothelial cells in vitro and angiogenesis in vivo [4].IFN- has strong anti-proliferative effects in glioblastoma cell lines and in vivo glioma cells expression of IFN- result in a significant inhibition of tumor growth [5, 6]
From October 2006 to August 2008, at the HHA were selected 10 patients to be treated with Center for Genetic Engineering and Biotechnology (CIGB)-128 as a palliative treatment
Thirty percent of patients stopped the treatment before a month because local infection at surgery site; death; tumor progression and seizures and pneumonia
Summary
IFN- has strong anti-proliferative effects in glioblastoma cell lines and in vivo glioma cells expression of IFN- result in a significant inhibition of tumor growth [5, 6]. CIGB-128 had an acceptable safety profile with fever as the most frequent adverse event, observed in 54.7%, followed by extrapyramidal symptoms and hypopotassemia in 14.2% of treated patients. Conclusions: CIGB-128 demonstrated signs of clinical improvement, with an acceptable safety profile and measurable improvement in quality of life in patients with non-operable or progressive highgrade glioma. The use of this drug should be explored further in clinical trials with a larger number of patients to confirm these encouraging results
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