Abstract
The self-association, optical transition probabilities, and hetero-association with chlorogenic acid of nicotinamide were obtained from UV-Vis spectroscopy in aqueous solution at room temperature (293K). The dimerization constant of nicotinamide ( ) was obtained using dimer model by nonlinear curve fitting technique. The hetero-association constant in the system of molecules of nicotinamide with chlorogenic acid were obtained in aqueous solution using a Benesi-Hildebrand equation. In order to characterize the binding system of the dimerization reactions for the self and hetero-association of the compound, the thermodynamic parameters were investigated using Vant’s Hoff equation at the temperature range (293 to 299K). As a result, the change of enthalpy obtained for the self and hetero-association is and respectively. The values of change in the thermodynamic parameters indicated that the hydrophobic interaction and electrostatic forces subsequently plays the major role in the binding reaction between the molecules of nicotinamide and its complexes with chlorogenic acid, respectively. In addition, the optical transition probabilities of nicotinamide were also calculated in the wavenumber regions by using integrated absorption coefficient techniques. Finally, the results of this study are very important for understanding the binding reaction in biological system, nature and strength of the transition in molecular interaction, absorption spectral interpretation, and in providing stringent test of atomic and molecular structure calculations in theoretical work of the compounds. Key words: Nicotinamide, chlorogenic acid, self-association, hetero-association, optical transition probabilities, thermodynamic properties, UV-Vis spectroscopy.
Highlights
Vitamins are organic chemical compounds, which are very important for an organism as a vital nutrient to sustain life since they play an important role in normal metabolism process, growth and vitality (Hassan, 2012)
The self-association, optical transition probabilities, and hetero-association with chlorogenic acid of nicotinamide were obtained from UV-Vis spectroscopy in aqueous solution at room temperature (293K)
It functions to the coenzymes nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADP), and is a precursor of essential enzymatic reactions in the body including adenosine triphosphate (ATP) production (Williams and Ramsden, 2005; Rolfe, 2014; Shalita and Smith, 1995; Jackson et al, 1995)
Summary
Vitamins are organic chemical compounds, which are very important for an organism as a vital nutrient to sustain life since they play an important role in normal metabolism process, growth and vitality (Hassan, 2012). (Vitamin B3) is an active, water soluble and amide form vitamin that is found in small amounts in natural foodstuff (Hassan, 2012) It can be obtained through synthesis in the body or as a dietary source and supplement of different food sources such as chicken, pork, beef, fish, legumes, nuts, grain products, mushrooms, yeast extracts, and coffee (Hassan, 2012; FSANZ, 2011; DiPalma and Thayer, 1991). Lack of nicotinamide leads to pellagra, fatigue, loss of appetite, pigmented rashes of the skin, oral ulcerations, dermatitis, dementia and death (Maiese et al, 2009; Hegyi et al, 2004)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
