Abstract
The self-association of amoxicillin (AMX) and its hetero-association with biologically active compound, chlorogenic acid (CGA) were investigated at room temperature (295°K). The dimerization constant of amoxicillin and thiamine (THIA) analyzed using the dimer model at the wavelength of 278 and 256 nm were found to be and , respectively. The hetero-association constant of amoxicillin and chlorogenic acid analyzed using Benesi-Hildebrand approach were . Thermodynamic parameters such as Gibbs free energy, enthalpy and entropy of dimerization reactions for the self-association and hetero-association of the compounds were also investigated using Vant’s Hoff equation at the temperature ranges (295 to 305°K). The change of enthalpy calculated for amoxicillin, thiamine and the complexes of amoxicillin-chlorogenic acid are 34.73±2.17, 54.1±4.585, and 6.988±0.493 at the temperature of 305°K, respectively. The values of change in enthalpy and entropy indicate that the hydrophobic interaction play the major role in the interaction between the molecules. Key words: Amoxicillin, thiamine, chlorogenic acid, UV-Vis spectroscopy, thermodynamic, self-association, hetero-association.
Highlights
Amoxicillin (AMX) is one of the most commonly prescribed penicillin
The change of enthalpy calculated for amoxicillin, thiamine and the complexes of amoxicillin-chlorogenic acid are 34.73±2.17, 54.1±4.585, and 6.988±0.493 kJ.mol 1 at the temperature of 305°K, respectively
The drugs, chlorogenic acid were purchased from Sigma-Aldrich and were used for measurements without any further purification
Summary
Amoxicillin (AMX) is one of the most commonly prescribed penicillin. It is orally active and acid stable belong to a class of drugs known as penicillinasesusceptible semi synthetic penicillin in which its stability in acid can be designed for oral use. It is absorbed more rapidly and completely from the gastrointestinal tract and excreted in an active form in the urine (Brunton et al, 2005; Delgado et al, 1995).
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