Abstract
Earlier study on thymine distribution in coding frames of mRNAs reveals that frame 1 prefers to have a defined number of thymine. The same in untranslated regions (UTRs) are further looked in to check this distribution in different frames. The results reveal that there is no such preference over the thymine distribution in different frames. Also confirms the earlier report of defined number of thymine in different frames of coding regions.
Highlights
The essential literature on untranslated regions is available in digital form globally
Beyond that what happens in thymine distribution in pre(5’untranslated regions (UTRs)) and post(3’UTRs) coding sequences? To compare this in UTRs, hundred UTRs human mRNAs are taken. These extracted 3’UTR, 5’UTR and coding sequences are grouped into different file and thymine contents were analysed
The thymine fraction in all these hundred sequences are computed and grouped based on thymine content as shown in [Table-2]
Summary
The essential literature on untranslated regions is available in digital form globally. During protein synthesis the initiation of translation mainly dependent on regulatory elements present in untranslated regions (UTRs). The regulatory proteins bind to these regions and initiate the synthesis. The up or down regulation of synthesis can cause disease [10] This well ordered UTR regions influence the rate of translation. The role of thymine in different frames mRNA sequences are reported by us [1]. It reports that the thymine in protein coding mRNAs is distributed with preference. The frame prefers to have definite amount of thymine. Whether the thymine distribution is same in frames of UTRs as in the case of coding mRNAs? Whether the thymine distribution is same in frames of UTRs as in the case of coding mRNAs? This has been addressed here
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