English

Abstract

Abstract Introduction In this review, we discuss the evidence for a novel receptor, vitamin D metabolite, 1,25-dihydroxyvitamin D 3 . The protein, which we have termed as the membrane-associ-ated, rapid response steroid-binding (1,25D 3 -MARRS) receptor, is iden-tical to ERp57/PDIA3. This protein has been extensively studied for its role in calcium and phosphate uptake in intestinal cells and more recently has been found to be implicated in cancer and Alzheimer’s disease. In addition, we present a more complete biochemical characterisation of this protein using co-immunoprecipita-tion and chromatin immunoprecipi-tation studies. Conclusion The 1,25D 3 -MARRS protein has both cytoplasmic and nuclear motifs and redistribution within the cell. New evidence shows its potential involve-ment through genomic action. Its involvement in disease states appears primarily through its chaperone action, post-translational modifica-tion of vital proteins and ability to modulate oxidative stress. Introduction