English

Abstract

Aim of the study was to study the effect of pneumoperitoneum on liver function tests, Serum aspartate aminotransferase (AST), Alanine aminotransferase (ALT), gamma glutamyl- transferase (GGT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in patients who had undergone laparoscopic cholecystectomy (LC) and to compare the alterations in liver function tests with those patients who underwent open cholecystectomy (OC). MATERIAL AND METHODS Indoor records of 201 patients were taken who were admitted to the hospital with complain of symptomatic gall stone diseases from 1 August 2011 to 31 Jul 2014. Out of 201 patients, 180 patients underwent Laparoscopic cholecystectomy at intraperitoneal pressure 12-15 mmHg and 21 patients underwent open cholecystectomy. Two groups were made for the purpose of study, laparoscopic cholecystectomy (LC) group and open cholecystectomy (OC) group. Serum levels of AST, ALT, GGT, LDH and ALP were assessed preoperatively and 24 hours after the surgery and finally at 3 weeks after the surgery, in both the groups i.e. Laparoscopic cholecystectomy (LC) group and open cholecystectomy (OC) group. Laparoscopic surgeries other than Laparoscopic cholecystectomy, CBD stone and CBD stricture, gas used other than CO2 for peritoneal inflation, Deranged LFT in pre- operative period were excluded from the study. RESULTS Statistical analysis revealed that there is significant alteration of liver enzymes AST, ALT, GGT and LDH in patients who underwent laparoscopic cholecystectomy compared with patients underwent open cholecystectomy. CONCLUSION Altered liver enzymes which occurred after laparoscopic cholecystectomy may be attributed to effect of intraoperative pneumoperitoneum on hepatic blood flow. Although most of these changes return to normal limit after 3 weeks of surgery, this does not seem to be clinically important but care should be taken before performing Laparoscopic cholecystectomy in patients with