English

Abstract

INTRODUCTION: Among Macrolide-Lincosamide-Streptogramin (MLS) antibiotics Clindamycin has been used most commonly because of its excellent pharmacokinetics. Because of increasing use, resistance to this drug is problem. The inducible resistance can only be detected if the erythromycin and Clindamycin discs are placed adjacent to each other. It is very important for each microbiology lab to check for inducible Clindamycin resistance. MATERIALS & METHODS: Total 325 Staphylococcus aureus isolates were studied. Isolates showing resistance to Erythromycin were tested for inducible Clindamycin resistance by disc approximation test, performed as per CLSI 2011 guideline S. RESULTS: 32% isolates were Methicillin Resistant Staphylococcus aureus (MRSA) and 68% were Methicillin Sensitive Staphylococcus aureus (MSSA). Inducible Clindamycin resistance was observed in 13.53% isolates, constitutive resistance was found in 12.61% isolates & MS phenotype was observed in 16.61% isolates. Inducible resistance, constitutive resistance and MS phenotype were higher in MRSA (27.80 %, 18.26% & 20.20% respectively) as compared to MSSA (6.78%, 9.95% & 14.93% respectively). CONCLUSION: Inducible Clindamycin resistance testing should be done as routine practice. IF not done it can lead to treatment failure and ultimately irrational use of other higher antibiotics. So there is need to guide the clinicians by delivering appropriate reports to prevent the stage of NO ANTIBIOTIC ERA