Abstract
English
Highlights
Primary intracranial lymphoma (PICL) is very rare, early diagnosis is difficult, and prognosis is poor; it accounts for 0.8-1.5% of primary intracranial tumors [1, 2], while primary intracranial lymphoma diffuse large B-cell lymphoma (PIC-DLBCL) accounts for 9598% of PICL
We studied and analyzed the characteristics of PIC-DLBCL through imaging, immunohistochemistry, gene rearrangement detection, and microRNA expression to discuss the clinicopathological characteristics of PIC-DLBCL and contribute to the understanding of its clinical character, tissue origin, diagnosis and prognosis
Light microscopy revealed centroblast-like large lymphocyte proliferation that surrounded the vessels
Summary
Primary intracranial lymphoma (PICL) is very rare, early diagnosis is difficult, and prognosis is poor; it accounts for 0.8-1.5% of primary intracranial tumors [1, 2], while primary intracranial lymphoma diffuse large B-cell lymphoma (PIC-DLBCL) accounts for 9598% of PICL. As there is no lymphatic circulation in the central nervous system, the origin and mechanism of neoplasia of lymphoma cells are unknown. We studied and analyzed the characteristics of PIC-DLBCL through imaging, immunohistochemistry, gene rearrangement detection, and microRNA expression to discuss the clinicopathological characteristics of PIC-DLBCL and contribute to the understanding of its clinical character, tissue origin, diagnosis and prognosis. Xu’e Han and Chengjun Xue contributed to this study. Received 21 July 2013 Revised 10 October 2013 Accepted 19 October 2013 Published 27 October 2013. Han X et al, J Cancer Res Ther 2013, 1(9):208214
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