Abstract
This study was aimed to investigate the protective, ameliorative and preventive effects of aqueous Date fruit extract on paracetamol induced nephrotoxicity in wistar rats. A total of 30 male albino wistar rats were used for this study. Rats were randomly divided into five groups containing 6 animals each. Treatments were given daily for fourteen days. The animals in the control group (Group I) did not receive any treatment, while those in group 2 received paracetamol (2 g/kg/day). Group 3 were pretreated with aqueous date fruit extract (400 mg/kg/day) for a week before paracetamol administration. Rats in group 4 received paracetamol (2 g/kg/day) for a week before treatment with aqueous date palm extract (400 mg/kg). Group 5 was administered paracetamol (2 g/kg/day) in concurrent with 400 mg/kg aqueous date fruit extract. Exposure of rats with a nephrotoxic dose of paracetamol disturbed the kidney function tests; blood urea nitrogen (BUN) and serum creatinine (SC) levels increased significantly (P>0.05). The protective use of aqueous date fruit extract on paracetamol-induced nephrotoxicity resulted in a significant improvement in most evaluated parameters. Key words: Date fruit, paracetamol, wistar rats, kidney.
Highlights
Medicinal plants continue to provide valuable therapeutic agents, both in modern and in traditional medicine (Abdelrahman et al, 2012; Iwu at al., 2014)
Nephro-protective effects of plant drugs and herbal formulations have been studied against chemicals and drugs induced nephrotoxicity in rats and mice, as they virtually mimic any form of naturally-occurring liver disease (Abdelrahman et al, 2012)
Ghosh et al (2010) observed that, exposure of rats with a nephrotoxic dose of Paracetamol altered a number of biomarkers
Summary
Medicinal plants continue to provide valuable therapeutic agents, both in modern and in traditional medicine (Abdelrahman et al, 2012; Iwu at al., 2014). Nephrotoxicity is one of the most common kidney. Some nephrotoxic compounds are arsenic, cadmium, copper, naturally-occurring plant toxins such as pyrrolizidine alkaloids, mycotoxins and bacterial toxins. Nephro-protective agents are those compounds which alleviate the kidney injury caused by nephrotoxic compounds. Nephro-protective effects of plant drugs and herbal formulations have been studied against chemicals (alcohol, CCl4, alcohol, beta galactosamine, thioacetamide) and drugs (paracetamol, nimusalide, antitubercular drugs like isoniazid etc.) induced nephrotoxicity in rats and mice, as they virtually mimic any form of naturally-occurring liver disease (Abdelrahman et al, 2012)
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