Effect of the Ethanolic Extract of Scoparia dulcis in Cisplastin induced Nephrotoxicity in wistar rats

Abstract

Abstract: Objective: To evaluate the nephroprotective potential of ethanolic extract of aerial parts of plant Scoparia dulcis against cisplatin induced nephrotoxicity in Wistar rats. Materials and Methods: Nephrotoxicity was induced by a single intra-peritoneal administration of Cisplatin (6 mg/kg) in wistar rats. Nephroprotective potential of plant was tested at two different doses in curative regimen and for a single dose of 400 mg/kg in prophylactic control. Nephrotoxicity was characterised by induced marked renal failure, significant increase in blood urea nitrogen, serum creatinine level, lipid peroxidation levels and significant decrease in urinary creatinine clearance. Histopathological studies confirmed tubular necrosis. Supplementation of ethanolic extract of Scoparia dulcis reduced the elevated serum creatinine, blood urea nitrogen levels, lipid peroxidation levels and improved the creatinine clearance. Results and Discussion: Our experimental results suggest that supplementation of Scoparia dulcis during cisplatin therapy reduces the risk of cisplatin induced nephrotoxicity in a dose dependent manner in curative regimen. The prophylactic regimen also possessed significant nephroprotection against cisplatin toxicity. The protective effect of Scoparia dulsis in curative and prophylactic regimen may be due to the antioxidant property of Scoparia dulcis. These findings suggest the significant nephroprotection of Scoparia dulcis against cisplatin nephrotoxicity. Key words: Nephrotoxicity, Scoparia dulcis, Cisplatin, lipid Peroxidation, anti-oxidant.