Abstract
Abstract: Objective: To evaluate the nephroprotective potential of ethanolic extract of aerial parts of plant Scoparia dulcis against cisplatin induced nephrotoxicity in Wistar rats. Materials and Methods: Nephrotoxicity was induced by a single intra-peritoneal administration of Cisplatin (6 mg/kg) in wistar rats. Nephroprotective potential of plant was tested at two different doses in curative regimen and for a single dose of 400 mg/kg in prophylactic control. Nephrotoxicity was characterised by induced marked renal failure, significant increase in blood urea nitrogen, serum creatinine level, lipid peroxidation levels and significant decrease in urinary creatinine clearance. Histopathological studies confirmed tubular necrosis. Supplementation of ethanolic extract of Scoparia dulcis reduced the elevated serum creatinine, blood urea nitrogen levels, lipid peroxidation levels and improved the creatinine clearance. Results and Discussion: Our experimental results suggest that supplementation of Scoparia dulcis during cisplatin therapy reduces the risk of cisplatin induced nephrotoxicity in a dose dependent manner in curative regimen. The prophylactic regimen also possessed significant nephroprotection against cisplatin toxicity. The protective effect of Scoparia dulsis in curative and prophylactic regimen may be due to the antioxidant property of Scoparia dulcis. These findings suggest the significant nephroprotection of Scoparia dulcis against cisplatin nephrotoxicity. Key words: Nephrotoxicity, Scoparia dulcis, Cisplatin, lipid Peroxidation, anti-oxidant.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Indian Journal of Pharmaceutical Education and Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.