Abstract
Folklore medicine in Sudan used medicinal materials to treat inestinal infections caused by bacterial infections or contamination of food. Methanolic and aqueous extracts of different parts of Acacia nilotica (L.) Delile gum, Haplophyllum tuberculatum Juss.aerial parts, Hydnora abyssinica A. Br.fruits, Nigella sativa L seeds, Rhynchosia minima (L.) DC. roots,and Usnea molliuscula lichen were tested for antibacterial properties at a concentration of 100 mg/mL against 20 intestinal isolates including Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Salmonella typhi, Salmonella para typhi B,Staphylococcus aureus, and standard bacterial strains (Bacillus subtilis (NCTC 8236), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 35657), Salmonella typhi (ATCC 1319106) and Staphylococcus aureus (ATCC 25923), using the Agar Diffusion Method. Standard antibiotics were used as standards drug for antibacterial effect. The highest enhancing properties were observed in methanol extracts and the lowest in aqueuos extract. U. molliuscula methanolic extract was the most active among all tested plant extracts, while, the aqueous extract of H. tuberculatum had a promising level of efficacy among the aqueous extracts tested. Most responsive Gram-negative clinical isolates bacteria were S. para typhi B and P. aeruginosa. Most susceptible standard bacteria were B. subtilis (NCTC 8236). Obtained results from investigated plants confirm their antibacterial potential and usefulness in the treatment of intestinal infections. Key words: Phytomedicine, traditional uses, antibactrial activity.
Highlights
The increasing incidence of antibiotic resistance has been increasing throughout the world in the last few decades (Abdallah, 2011).This has led to higher mortality in humans
One of the most intensive researched fields is the search for material with high antibacterial potency, with folklore medicine being a prime area.In this regard Sudan has a long history of traditional use of plants to treat primry health issues.very little research is directed towards understanding their potential for curing gastrointestinal
Aqueous extract of U. molliuscula lichen did not exhibit antibacterial properties against all tested bacteria.The obtained results may account for the reason people in Sudan refuse to use aqueous extract countiniously as a treatment of gastrointestinal tract
Summary
The increasing incidence of antibiotic resistance has been increasing throughout the world in the last few decades (Abdallah, 2011).This has led to higher mortality in humans. One of the most intensive researched fields is the search for material with high antibacterial potency, with folklore medicine being a prime area.In this regard Sudan has a long history of traditional use of plants to treat primry health issues.very little research is directed towards understanding their potential for curing gastrointestinal. Spread and prevelence of microbial resistance is geting more frequent worldwide (WHO, 2001). Search for new antimicrobial substances is the major weapon to combat the microbial resistance through developing new antibacterial materials to substitute with inefficient ones
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