Abstract
Two iron(III) complexes of Ciprofloxacin were synthesized by reaction of the ligand with iron(III) chloride hexahydrate in different solutions. The nature of bonding of the ligands and the structure of the isolated metal complexes were elucidated on the basis of their physical and spectroscopic studies. The infrared spectra suggest that two classes of compounds were obtained: molecular complex in which the ligands were bidentately bonded to the metal through the ring carbonyl oxygen and one of the oxygen of the carboxylate group and the ionic complex consisting of a tetrachlorometalate ion which is electrostatically attached to the ligand. The antibacterial activities of the products against various microorganisms were tested and it was established that their activities were comparable with those of their parent drug. Toxicological studies were carried out in which therapeutic doses of the Ciprofloxacin drug and the metal complexes were administered to albino rats and the results showed that the metal complexes are not toxic. Key words: Quinolone, fluoroquinolone, Ciprofloxacin, metal complexes, toxicological study, antimicrobial study.
Highlights
According to Chu et al (1996) there is a worldwide agreement over the present need to develop novel agents to treat bacterial infections that have become increasingly unresponsive to standard antibacterial therapy
This indicates that the carboxylic group is not deprotonated, the Ciprofloxacin ligand is not directly coordinated to the metal
The observed reduction in liver-body weight ratio caused by Ciprofloxacin and its metal complexes suggests that the drugs may retard the growth of the liver
Summary
According to Chu et al (1996) there is a worldwide agreement over the present need to develop novel agents to treat bacterial infections that have become increasingly unresponsive to standard antibacterial therapy. Emergence of bacteria resistance to a number of antimicrobial agents is becoming a major health problem. This has led to studies on the metal complexes of 1-. 3-quinoline carboxylic acid hydrochloride (C17H18FN3O3.HCl.H2O) (Ciprofloxacin), a fluoroquinolone derivative, in which biological studies were carried out to determine their potency The complexes showed comparable antimicrobial activity with the free ligand. Antimicrobial assay and toxicity studies of Ciprofloxacin (Figure 1) and two synthesized and analyzed iron (III) complexes of Ciprofloxacin were carried out
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