Abstract
Gastric ulcers are mucosal lesions that result from an imbalance between aggressive factors such as acid and pepsin, and defensive mechanisms like gastric mucous, high mucosal blood flow and high mucosal turnover rate that work towards maintenance of mucosal integrity. The aetiology of gastric ulcers is not completely understood and continuous use of anti-ulcer agents leads to many side effects. In the present study, the unsymmetrically substituted urea derivative (1-benzyl-3-(4-methylphenyl) urea) was tested for the anti ulcerogenic activity of alcohol and aspirin induced ulcer models on rats. Ulcer index was calculated by histopathological studies. The test compound at a concentration of 50 and 100 mg/kg exhibited a protective effect on ulcer-induced models in a dose dependent manner, and was comparable with the standard drug ranitidine. These findings indicate that unsymmetrically substituted urea derivative has ulcer protective activity.
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