Abstract

3,5-Dimethylpyrazole (U-6245) is a hypoglycemic and antilipolytic agent used in the treatment of diabetes mellitus. Complex 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper was prepared in 2009. This study indicated that 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3- oxapentane-diacetatocopper has hypoglycemic properties by decreasing glucose level in blood but caused histopathological changes in the pancreas rats. Rats treated with 1,5-Bis(3,5-dimethylpyrazol-1- yl)-3-oxapentane diacetatocopper for 2, 4 and 6 weeks revealed inflammatory infiltration in the pancreas, marked cytoplasmic vacuoles, congestion of blood vessels with edema and haemorrhage, as well as, some of the degenerated cells showed necrosis. Large spaces were detected in some areas due to degeneration of cells. Sera of animals treated with 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in the present study revealed a significant decrease in serum glucose after 2, 4 and 6 weeks of treatment. Key words: Hypoglycemic agent, glucose, pancreas, necrosis.

Highlights

  • The pancreas is an organ composed of endocrine and exocrine tissue

  • The endocrine pancreas consist of islets of langerhans which secrete hormones and the exocrine pancreas contains many secretary units called acini arranged around a system of ducts

  • Rats treated with 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3oxapentane diacetatocopper exhibited many histopathlogical changes in pancreas

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Summary

Introduction

The pancreas is an organ composed of endocrine and exocrine tissue. The endocrine portion is the islets of langerhans, contains β-cells that secrete insulin hormone. Storage and use of glucose by tissues. These activities result in a decrease in the level of blood glucose (Butler, 1995). Diabetes mellitus is a disease t h a t leads to complications including heart disease, kidney failure and nerve damage (Butler, 1995). The search o f highly efficient therapeutic drugs for the prevention and treatment of diabetes are one of the main objectives of modern medicine (Richard et al, 2010)

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