English

Abstract

Diabetes-associated oxidative stress causes glomerular hypertrophy, decrease of glomerular filtration rate and inhibits cell proliferation that lead to the decrease of renal function as indiated by the increase of serum creatinine level and the presence of protein in urine. Mahogany seed (Swietenia macrophylla King) has been proven to have antidiabetic activity. This study was conducted to evaluate the effect of the ethanolic extract of mahogany seeds on the renal function of streptozotocin-induced diabetic rats. Six normal rats as control (Group I) and 24 diabetic rats were used in this study. The diabetic rats were randomized allocated into four groups with six rats in each group. Group II was considered as diabetic rats control and received aquadest. Group III-V were considered as extract administered diabetic group and received ethanolic extract of S. macrophylla seed for 21 days at a dose of 50, 100 and 200 mg/kg BW, respectively. Serum malondialdehyde (MDA), serum creatinine, and urine protein levels were monitored, before and after the ethanolic extract of S. macrophylla seed administration. Serum MDA, serum creatinine and urine protein levels of all rats after STZ induction (Group II-V) were significantly higher than without STZ induction (p < 0.05). A significant decrease in the serum MDA and serum creatinine as well as urine protein levels were observed after the treatment with ethanolic extract of S. macrophylla seed compared to before treatment (p < 0.05). In conclusion, the ethanolic extract of S. macrophylla seed is able to correct renal dysfunction of streptozotocin-induced diabetic rats.