Abstract
Ever since it was first described by Billroth, there is an increasing incidence of multiple primary malignancies cases, due to increase in the survival rate of cancer patients and improvement of diagnostic tools. Incidence of second malignancies in cancer patients is 10 to 20%. A total of 10 patients who fulfilled the inclusion criteria were included. All the 10 patients’ case sheets were pursued, and the biochemical, radiological and histopathological reports were analyzed. Results revealed that out of the 10 patients, five were synchronous and the other five were metachronous with a median age of 59 years. Four male patients and six female patients are included. The most common malignancy sites were the stomach and breast, and the mean time interval between both the metachronous tumors is 7.2 years. Thus, a strong clinical suspicion is needed for detecting the multiple primary malignancies, anda treatment plan should be formulated individually for every case. Key words: Neoplasm, multiple primary, synchronous neoplasm, metachronous neoplasm, therapeutics.  
Highlights
The incidence of double primary malignancy is not very rare, Billroth has reported the first case in 1889 (Chakrabarti et al, 2015; Sehgal et al, 2018), while the first statistical analyses was reported by Bugher in 1934 (Sehgal et al, 2018; Sharma et al; 2016)
The aim of this research is to study the incidence of multiple primary malignancies
The most common presenting malignancy in cases of synchronous tumor is breast with two cases (40%) followed by stomach, anal canal and nerve sheath tumor with one case each (Figure 4).The common identified malignancy in cases of synchronous tumors is stomach (40%) and thyroid (40%) with two cases each followed by one case of carcinoma breast (20%)
Summary
The incidence of double primary malignancy is not very rare, Billroth has reported the first case in 1889 (Chakrabarti et al, 2015; Sehgal et al, 2018), while the first statistical analyses was reported by Bugher in 1934 (Sehgal et al, 2018; Sharma et al; 2016). Incidence of double primary malignancies has been underreported due to the difficulties in epidemiological data collection and is allegedly between 2.4 and 17%. With the improvement in medical treatment modalities and imaging techniques (positron emission tomography), there is arise in the incidence of double primary malignancy as the overall survival rate of cancer patients has increased (Chakrabarti et al, 2015; Sehgal et al, 2018). The aim of this research is to study the incidence of multiple primary malignancies
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