Abstract
The effects of oral intake of capsaicin oleoresin (CO) on arterial blood pressure was examined in male spontaneously hypertensive (SHR) rats. Animals were randomized into control (C), capsaicin oleoresin (CO), capsaicin oleoresin-irbesartan (COI) and capsaicin oleoresin-amlodipine besylate (COAB) fed groups. The experimental groups received 50 mg of Capsaicin Oleoresin only, CO with 25 mg of Irbesartan, and CO with 2.5 mg of Amlodipine per kilogram of body weight every other day for 4 weeks. Blood pressure was measured weekly by tail-cuff for 4 weeks. Biological samples were obtained at baseline, day 18, and day 34 (terminal) for aldosterone, arginine vasopressin (AVP), renin, 6-Keto-PGF-1α, Prostaglandin E2, catecholamines, adrenocorticotropic hormone (ACTH) levels, and serum minerals. Statistical significance was set at p≤0.05. The results trended towards decreasing (p=0.190) systolic blood pressure (SBP) in the COAB and CO compared to the COI and control groups. However, significance among group differences were observed for urine aldosterone and AVP, and serum sodium, calcium, magnesium, potassium, and catecholamine (p≤0.05), but not for ACTH, renin, and 6-Keto-PGF-1α levels. Capsaicin treatment was non-significantly associated with decreased SBP in SHR. These findings suggested that the effects of Capsaicin on SPB may involve aldosterone and arteriolar vascular tone. Key words: Capsaicin oleoresin, amlodipine besylate, irbesartan, arginine vasopressin, spontaneously hypertensive rats.
Highlights
Are the morbidity and mortality rates of hypertension high in many countries in the world, hypertension affects people of every culture, gender, race, and socio-economic class
The capsaicin oleoresin-irbesartan (COI) group had an insignificant mean increase in diastolic blood pressure (DBP) during the treatment period compared to baseline
The capsaicin oleoresin-amlodipine besylate (COAB) group had the lowest change in urine aldosterone level, followed by the capsaicin oleoresin (CO), and COI groups respectively (Figure 2)
Summary
Are the morbidity and mortality rates of hypertension high in many countries in the world, hypertension affects people of every culture, gender, race, and socio-economic class. The roles of nutrition and hormonal imbalances in hypertension are widely known, and the research findings have resulted in the successful development of drugs to ameliorate the disorder. Capsaicin is the active ingredient in the genus Capsicum, commonly called chili Their fruits, chili peppers, are consumed all over the world in different shapes and sizes and vary in the extent of the sensory heat produced by the irritation of mucus membranes (Okeahialam et al, 1998). These fruits have been used in the pharmaceutical industry as topical pain remedies and for drug development
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