Abstract
English
Highlights
The biologic rhythms are physiological circumstances that provide the adaptation of an organism to the external environment in the absence of environmental time determinants (Chassard and Bruguerolle, 2004)
Total intravenous anesthesia (TIVA) with target controlled infusion (TCI) technique using propofol and remifentanil was utilized in anesthesia induction and maintenance of all patients
The onset time of rocuronium did not differ between 4 groups with a mean (SD) of 2.65 (1.0) min
Summary
The biologic rhythms are physiological circumstances that provide the adaptation of an organism to the external environment in the absence of environmental time determinants (Chassard and Bruguerolle, 2004). The chronobiology investigates these rhythms and their mechanisms. Rocuronium is the most rapid onset and the most commonly used nondepolarizing muscle blocker currently available Factors such as age (Baykara et al, 2002), weight (Leykin et al., 2004), temperature of the patient (Beaufort et al, 1995), as well as the anesthetic agent used for anesthesia maintenance (Maidatsi et al, 2004) affect the duration of action of rocuronium. One study was undertaken to evaluate the influence of time of day on the clinical duration of rocuronium in the available literature (Cheeseman et al, 2007). We have undertaken a study to in-vestigate whether the dosing-time of rocuronium would cause significant differences in the neuromuscular block duration during the whole day in a diurnal based study design
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