Abstract
Agaricus brasiliensis is a valuable food mushroom that exhibits several pharmacological activities. The beneficial effects of the A. brasiliensis methanol extract on skin health have never been investigated. The purpose of this study was to evaluate the potential skin care effects of extract from A. brasiliensis. The results reveal that A. brasiliensis methanol extract exhibited apparent inhibitory effects on melanin synthesis and suppressed the expression levels of melanogenesis-related proteins. Also, the extract depleted the intracellular level of the reactive oxygen species (ROS). The methanol extract inhibited mushromm tyrosinase activity, suppressed intracellular tyrosinase activity (IC50 = 0.713 mg/mL) and decreased the amount of melanin (IC50 = 0.711 mg/ml) in B16F10 cells. The protein expression levels of tyrosinase and tyrosinase-related protein 1 (TRP 1) were decreased by the methanol extract. Our results show that A. brasiliensis methanol extract inhibited melanogenesis and depleted intracelluylar ROS in B16F10 cells. Thus, A. brasiliensis methanol extract could be applied as a type of natural skin depigmentinging agent in skin care products. Key words: Agaricus brasiliensis, tyrosinase, melanin, reactive oxygen species (ROS).
Highlights
IntroductionCalled Agaricus blazei Murill, is a mushroom native to Brazil and is currently popular in the market in Taiwan
Agaricus brasiliensis, called Agaricus blazei Murill, is a mushroom native to Brazil and is currently popular in the market in Taiwan
The results reveal that A. brasiliensis methanol extract exhibited apparent inhibitory effects on melanin synthesis and suppressed the expression levels of melanogenesis-related proteins
Summary
Called Agaricus blazei Murill, is a mushroom native to Brazil and is currently popular in the market in Taiwan. It has been reported as a functional health food for its use as a complementary and alternative medicine by cancer patients (Talcott et al, 2007). A broad spectrum of biological activities has been attributed to this mushroom including antibacterial, antiparasitic, antiviral, antitumoral and anti-genotoxic actions. There are limited reports on the beneficial effects of A. brasiliensis on skin health. Our previous study revealed that aqueous and ethanol extracts of A. brasiliensis provide inhibitory effect on mushroom tyrosinase activity (Chien et al, 2008), which suggested that this edible mushroom could be effective in reducing melanin production in melanocytes
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