Abstract
Nearly one third of protein in the body consists of collagen. It plays a key role in providing the structural scaffolding for cells, tissues, and organs. With available literature, we show that prolonged exposure of cultures of human connective-tissue cells to ascorbate (vitamin C) induces an eight-fold increase in the synthesis of collagen with no increase in the rate of synthesis of other proteins. Making advantage of increased degree of polarization due to enhanced rate of collagen biosynthesis in the presence of vitamin C, we propose a better imaging modality for diagnosing thermal damage in human tissues. Key words: Collagen, vitamin C, triple helix, birefringence, optical coherence tomography.
Highlights
Skin is made up of three layers viz., the epidermis, the dermis and the fat layer
Stokes parameter images of light backscattered from skin will significantly change due to any change in the conformation of collagen by any means as this will lead to change in birefringence
The ratio of rate of administration of Vitamin C to the rate of production of Placebo an experiment was studied on a population of 10 subjects. (Placebo means an inactive substance or preparation used as a control in an experiment or test to determine the effectiveness of a medicinal drug.) The subjects were treated with w/o emulsion containing 5 % L- ascorbic acid on the external arm [A] and femw/o emulsion (Placebo) [P] on the external face of the other arm, daily for 6 months and the number of copies per unit of mRNA was examined
Summary
Skin is made up of three layers viz., the epidermis, the dermis and the fat layer. The dermis composed largely of the protein collagen. We show that prolonged exposure of cultures of human connective-tissue cells to ascorbate (vitamin C) induces an eight-fold increase in the synthesis of collagen with no increase in the rate of synthesis of other proteins. Making advantage of increased degree of polarization due to enhanced rate of collagen biosynthesis in the presence of vitamin C, we propose a better imaging modality for diagnosing thermal damage in human tissues.
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