Abstract
Prostate develops from a series of endodermal buds from the lining of primitive urethra and the adjacent portion of urogenital sinus during the first 3 months of intra-uterine life. A prostate needle biopsy is a surgical procedure in which a small sample of tissue is removed from the prostate gland and examined under the microscope by a pathologist. In all investigated individuals, the level of prostate-specific antigen (PSA) was determined in identical way. PSA was estimated in venous blood by electro-chemiluminescence method. Histopathological analysis of obtained material was done on standard hematoxylin-eosin (H&E) preparations. Out of 60 patients studied, most of the patients 30 (50%) were diagnosed with benign prostatic hyperplasia (BHP). Higher levels of PSA (>20) was found in 57.1% of patients of BHP with chronic prostatitis table 11. Out of the total number of adenocarcinoma patients, 77.8% of the patients were having preoperative PSA levels greater than 20. In our study, the positive predictive value for increasing PSA levels was 8.3% for PSA <4 ng/ml, 16.6% for PSA >4 ng/ml, 24.2% for PSA >10 ng/ml and 83.3% for PSA >100 ng/ml. Key words: Prostate, lesions, histopathology, needle biopsies, serum prostate-specific antigen (PSA).
Highlights
Prostate develops from a series of endodermal buds from the lining of primitive urethra and the adjacent portion of urogenital sinus during first 3 months of intra-uterine life
Histopathologic diagnosis was made as benign prostatic hyperplasia (BHP), chronic prostatitis, basal cell hyperplasia, prostatic intraepithelial neoplasia (PIN), adenocarcinoma and atypical suspicious of malignancy
It has been estimated that over 200,000 men in United States are diagnosed annually with prostate cancer and 300,000 men still die from this disease each year
Summary
Prostate develops from a series of endodermal buds from the lining of primitive urethra and the adjacent portion of urogenital sinus during first 3 months of intra-uterine life. The glandular component is composed of acini and ducts. Both acini and ducts contain secretory cells, basal cells and neuroendocrine cells. The columnar secretory cells, stain positively with prostate specific antigen and prostatic acid phosphatase (Bostwick et al, 1997). The cells co-express PSA and prostatic acid phosphatase. Their function is unclear but it is speculated that these cells are involved with local regulation by paracrine release of peptides (Epstein, 1997). The prostate becomes more complex with ducts and branching glands arranged in lobules and surrounded by stroma with advancing age. A prostate needle biopsy is a surgical procedure in which a small sample of tissue is removed from the prostate gland and examined under the microscope by a pathologist. This study was conducted on 60 patients present with abnormal digital rectal examination (DRE) or elevated serum PSA of >4 ng/ml or both abnormal DRE and elevated serum PSA
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