English

Abstract

Propofol is commonly used newer induction agent of choice with smooth and rapid recovery from anaesthesia. It has one adverse effect which is restricting its use i.e. pain during injection. We in present study are comparing Ondansetron with Lignocaine to alleviate pain during injection of Propofol, as ondansetron is routinely used to prevent post-operative nausea and vomiting, so it can have both effects viz prevention of pain on injection of Propofol and prevention of post-operative nausea and vomiting. The aims of study were to evaluate incidence to alleviate pain during injection of propofol, efficacy of Ondansetron & Lignocaine to alleviate pain during injection of propofol, incidence and severity of pain in Ondansetron and Lignocaine group, incidence of side effects in both groups. MATERIAL AND METHODS: The present study was carried out in S.R.T.R. Govt. medical college and hospital Ambajogai after ethical committee approval. 120 patients of ASA grade I and II of either sex undergoing short surgical procedures requiring general anaesthesia without endotracheal intubation were randomly allocated to three equal groups of 40 patients each :Group I: Received 0.9% Normal saline (2ml) as pretreatment, Group II: Received 2% lignocaine hydrocloride (2ml) as pretreatment, Group III: Received 4mg ondansetron (2ml) as pretreatment. EXCLUSION CRITERIA: patients with history of allergy to propofol, neurological disorders or altered sensorium or those on anti-psychotropic medication and patient with cardiac conduction abnormalities. It was pre decided that patients with sedation score of >3 would be excluded from study, however none of the patients in our study had sedation of >2 with 1/4 th calculated dose of propofol. Assessment of pain was done using Verbal Pain score and Face pain score. OBSERVATION: Statistical analysis was done by ANOVA test while comparing 3 groups and by Z test while comparing group II & III. Incidence of pain was more in control group than study groups & difference was statistically significant. There was no significant difference in adverse effects. CONCLUSION: Pretreatment with either Lignocaine or Ondansetron can be used to alleviate incidence of pain on Propofol injection with cardiovascular stability and minimal side effects.