A RANDOMIZED CONTROLLED TRIAL COMPARING ONDANSETRON AND LIDOCAINE FOR REDUCING PROPOFOL INJECTION PAIN.

Abstract

Introduction: Propofol injection pain is common and causes people to suffer during general anesthetic induction. The incidence of injection pain has been estimated to range between 28 - 90% [1]. Pretreatment with lidocaine and venous occlusion before propofol injection proved to be the most effective strategy. Ondansetron had a substantial inuence on pain reduction following propofol injection. We hypothesized that pretreatment with ondansetron would reduce the pain associated with propofol injection. AMethods: randomized controlled trial was conducted after approval by the Institutional Ethics Committee of Sham Shah Medical College Rewa (IEC- SSMC-150). We recruited 150 patients of both genders, American Society of Anesthesiologists physical (ASA) status I–III, and aged between 18–65 years old, undergoing elective surgeries under general anesthesia between November 2020 to November 2021. Patients who weighed less than 50 kg, were allergic to ondansetron, lidocaine, or propofol, and had cardiac arrhythmias, who did not receive propofol for induction, were all excluded from the study. Each group of 75 patients received either 8 mg. of ondansetron (Group RDO) or 40 mg. of lidocaine (Group RDL). Patients were asked to rate their pain at the injection site using a verbal numerical rating score (VNRS), The post-anesthetic care unit assessed postoperative nausea and vomiting (PONV). There were no signicant differences between the groups in terms of gender, age, and bodyResults mass index (BMI) (Table 1). The incidences of no pain, mild, moderate, and severe pain were also signicantly different in the RDL group (33.3 percent, 40 percent, 21.3 percent, and 5.3 percent, respectively) when compared to the RDO group (14.5 percent, 30.6 percent, 30.6 percent, and 14.2%respectively) (P = 0.01) (Table 2). There were no signicant differences in the rates of postoperative nausea and vomiting among the two groups In conclusion preparation with 8 mg. intravenous ondansetron before induction did not signicantly lower the incidence and intensity of propofol-induced pain. Also, there was no advantage to preventing nausea and vomiting after surgery.