Abstract
NSAIDs are frequently used for relief of inflammation and Antihistaminics are indicated for simultaneous administration for allergic manifestations. Opioids analgesics have been reported to interact with Antihistaminics. To explore the interacting potentiality, in the present study the effects of combined treatment with NSAIDs and antihistaminics were examined in rats. Anti-inflammatory effect was evaluated by Carrageenan induced hind paw oedema in rats. NSAIDs like aspirin, ibuprofen and piroxicam were selected for study on per se and on concurrent administration with Antihistaminics such as Promethazine, Cetrizine and Astemizole. All NSAIDs protected animals show anti-inflammatory activity. Aspirin shows highly significant potentiation of anti-inflammatory effect at all dose level, however ibuprofen and piroxicam show highly significant anti-inflammatory effect at higher doses only and on concurrent administration of antihistaminics, aspirin, piroxicam and ibuprofen with all antihistaminics produced highly significant potentiation except ibuprofen with Cetrizine produced significant potentiation of anti-inflammatory response at higher doses only.
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