Abstract
Defensin is a small, cysteine-rich, cationic peptides family with antimicrobial and cytotoxic properties. Among all known defensins, neutrophil peptide-1 (NP-1), which is expressed mainly in rabbit neutrophils, has a broad resistance spectrum to pathogens such as Treponema pallidum , many Grampositive bacteria, Gram-negative bacteria, fungi, viruses. Besides, it has the same striking inhibition or toxic effect on some nausea and tumor cells. Due to the broad antibacterial spectrum and special mechanism of microbial inhibition, rabbit defensin has been transformed into some plants and expressed via genetic engineering. And it plays an important role in genetic engineering of anti-disease plants and plants species’ improvement. This article reviewed and discussed the advantages and research progress of the rabbit defensin genetic engineering of plant in recent years, and also focuses on the existing problems and new strategies in this area. Key words: Rabbit defensin (NP-1), structure, bioactivity, genetic engineering of plant.
Highlights
Research on disease resistance plant, especially in the field of disease resistance transgenic plants obtained, has attracted much attention and got some achievements in recent years
The spectrum antimicrobial of many disease resistance genes is not broad enough, which could be used to design for just one kind of sickness and resist only one or other relative disease(s); on the other hand, it is not easy to identify the genes that resist some pathogenic bacteria
It has striking inhibition or toxic effect on the Treponema pallidum, many Gram-positive bacteria, Gram-negative bacteria, fungi, viruses; besides, it has the same effect on some nausea and tumor cells
Summary
Research on disease resistance plant, especially in the field of disease resistance transgenic plants obtained, has attracted much attention and got some achievements in recent years. The spectrum antimicrobial of many disease resistance genes is not broad enough, which could be used to design for just one kind of sickness and resist only one or other relative disease(s); on the other hand, it is not easy to identify the genes that resist some pathogenic bacteria. Since the rabbit defensin embraces many bioactivities and makes target microbes hard to generate disease resistance mutations, it has a bright future in research of disease resistance plant application as a new antibiotic. There are a lot of cationic antimicrobial peptides with small molecular mass in the rabbit neutronphils, which are from the same gene family, grouped into α-defensin (Zeya and Spitznagel 1968, 1963). There are a lot of cationic antimicrobial peptides with small molecular mass in the rabbit neutronphils, which are from the same gene family, grouped into α-defensin (Zeya and Spitznagel 1968, 1963). α-Defensin is thought to have the following structural characteristics: Ting et al 9219
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
