Abstract
Pseudomonas aeruginosa (P. aeruginosa) has been found to be a common hospital acquired pathogen, responsible for several severe infections. The objective of this study was to describe the antibiotic resistance profile of P. aeruginosa strains from human sample. This descriptive study was carried out on 168 isolated strains of P. aeruginosa collected from January 2014 to December 2015 at the Pasteur Institute of Cote d'Ivoire. The strains identification was done according to the methods of conventional bacteriology. The antibiotic sensitivity tests were performed using the disc diffusion method in agar medium according to CA-SFM (Antibiogram committee of French society of microbiology) criteria. The serotyping of the strains was carried out by using the agglutination method slide test, with the aid of 4 specific polyvalent antisera. The most prevalent P. aeruginosa serotypes were O4 (24.4); O11 (14.6); and O6 (9.5%). The rate of antibiotic resistance to ticarcillin was 32.9%, ciprofloxacin 18.4%, ceftazidime 14.9%, Imipenem 11.3%, and amikacin 11.3%. Resistance to Imipenem was above 10% in an intensive care unit and in the pneumonology unit (PPH). Strains of O6 serotypes were the most multidrug-resistant followed by O11 with respective rates of 31.2 and 28% MDR (Multidrug Resistance). P. aeruginsa are microorganism capable of developing mechanisms of complex resistance which makes it difficult to manage. The attention of hygiene rules and the rational use of antibiotics are very important in other to prevent the spread of MDR P. aeruginosa. Key words: Pseudomonas aeruginosa, serotype, multidrug-resistance, infection.
Highlights
Pseudomonas aeruginosa has become a major hospital acquired pathogen, responsible for several severe infections (Bertrand et al, 2013)
Due to its natural resistance to many antibiotics and its ability to build up new resistance, the hospital environment favors the growth of P. aeruginosa despite multiple antibiotic selection pressure
P. aeruginosa were isolated from different biological fluid at variable frequencies, pus (51.8%), followed by pulmonary secretions (19%), urine (9.5%), blood (7.7%), Invasive material (7.7%) and cerebrospinal fluid (3.6%)
Summary
Pseudomonas aeruginosa has become a major hospital acquired pathogen, responsible for several severe infections (Bertrand et al, 2013). Due to its natural resistance to many antibiotics and its ability to build up new resistance, the hospital environment favors the growth of P. aeruginosa despite multiple antibiotic selection pressure. The emergence of multidrug-resistant strains of P. aeruginosa in hospital is often associated with some serotypes (Thrane et al, 2015). In order to find an epidemiological link between the strains of P. aeruginosa isolated in hospital, phenotypic markers such as antibiotype and serotype are used to differentiate strains before genetic characterization (Blot et al, 2013; Wolska et al, 2012). The aim of this study was to evaluate the antibiotic resistance profile of P. aeruginosa and to compare these profiles with serotypes of isolated strains
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