Drug resistance of Staphylococcus aureus in a hospital from 2012 to 2016

Abstract

Objective To investigate the distribution and drug resistance of Staphylococcus aureus from 2012 to 2016 and provide some evidences for the rational use of antibiotics in clinic. Methods 1016 strains of Staphylococcus aureus isolated from all specimens at our hospital in recent five years were collected. Strain identification and drug sensitivity test were takeg by identified with French bioMerieux ATB semi automatic identification and drug sensitivity analyzer and BD automatic identification and drug sensitivity analysis system (BD PHOENIX-100). The methicillin resistant staphylococcus aureus (MRSA) was screened by disc diffusion method (K-B method). Statistical analysis was performed using WHONET5.6 software version. Results 1016 strains of Staphylococcus aureus were isolated in the recent 5 years. The detection rate of MRSA was 31.99%. The drug sensitivity results showed that staphylococcus aureus was highly resistant to penicillin, erythromycin, and clindamycin (40.0%-97.2%). The resistant rates of quinolones, sulfonamides, and Amikacin were low (5.0%-30.0%). MRSA was more resistant to commonly used antimicrobial drugs than MSSA. No strains of staphylococcus aureus were resistant to vancomycin, linezolid, and teicoplanin. Conclusion The annual detection rate and drug resistance rate of Staphylococcus aureus at our hospital are relatively constant; and the rational use of antibiotics and strict disinfection and isolation measures should be further strengthened. Key words: Staphylococcus aureus; Resistance; Staphylococcus aureus resistant to methicillin (MRSA)