Analysis of pathogenic bacteria and drug resistance in 102 children with bone and joint purulent infection

Abstract

Objective To summarize the bacterial types and drug resistance of children with bone and joint purulent infection in the Affiliated Hospital of Zunyi Medical College in recent 9 years, so as to provide reference for rational use of antibiotics in clinics. Methods A retrospective study was performed on the clinical data of 102 children with hematogenous bone and joint purulent infection in the Affiliated Hospital of Zunyi Medical College from January 2008 to October 2016, in which there were 57 boys and 45 girls with a mean age 5.5 years old(from 10 days to 14 years old), among which 38 cases were acute osteomyelitis, 30 cases were pyogenic arthritis, 27 cases were chronic osteomyelitis, and 7 cases were arthritis with hematogenous osteomyelitis.The results of blood culture, pus culture and antibiotic sensitivity test results were analyzed and summarized. Results The results of blood culture or pus culture in 102 cases were all infected by single bacteria, including 89 cases of staphylococcus aureus(SA), accounting for 87.30%, 3 cases (2.94%) of micrococcus scarlatinae, 2 cases (1.96%) of klebsiella pneumoniae, 2 cases (1.96%) of staphylococcus haemolyticus, and 1 case (0.98%) of methicillin-resistant staphylococcus epidermidis, streptococcus pneumoniae, streptococcus mitis, enterococcus hirae, enterobacter cloacae and pseudomonas aeruginosa, respectively.The resistance rate of SA to penicillin was 92.1%, but to Lincomycin, Erythromycin, Cefoxitin and Tetracycline it was more than 50.0%, and to Sulfamethoxazole, Gentamicin and Rifampicin it was quite low, and the resistant strains to Linezolid, Quinupristin/Dafoe Putin, Mo Xisha star, Tigecycline, Vancomycin, Levofloxacin, Nitrofurazone were no found.There were not multi drug resistant strains to be found except in the 45 cases of methicillin-resistant staphylococcus aureus(MRSA)and 1 case of methicillin-resistant staphylococcus epidermidis. Conclusion SA is the main pathogenic bacteria of bone and joint purulent infection in children in the local area. The resistant rate of penicillin and the detection rate of MRSA are high in the hematogenous osteoarticular infections caused by SA, but no vancomycin resistant cases were found. Key words: Bone and joint; Infection; Pathogenic bacteria; Drug resistance