Abstract
English
Highlights
Polyamines are essential for diverse biological functions in prokaryotic and eukaryotic cells
The analysis revealed that several transporter genes including DUR3 and SAM3, as well as SKY1 are downregulated in the agp2Δ mutant, while several others are unaffected such as GAP121
Since Sky[1] kinase does not affect the expression of the polyamine transporter genes DUR3 or SAM3, there is a distinct possibility that it could act to maintain the activity of these transporters
Summary
Polyamines are essential for diverse biological functions in prokaryotic and eukaryotic cells Both endogenous synthesis and uptake by means of active transport mechanisms provide the pool of intracellular polyamines. Targeting one of the rate limiting enzymes, ornitine decarboxylase, in the polyamine biosynthetic pathway with a specific suicide inhibitor, α-difluoromethylornithine, has been employed as a chemotherapeutic agent, but with limited success. This failure can be attributed to compensatory mechanisms that maintain polyamine levels such as increase uptake from extracellular sources[11]. A combine approach that uses inhibitors to deplete the endogenous pool of polyamine and polyamine-conjugated anticancer drugs that damage the DNA should greatly improve the treatment of cancer cells. The aim of this review was to discuss Agp[2] and its role as a regulator of polyamine uptake that signals gene expression
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