Abstract
Two major compounds, stigmasterol (ST) and sitosterol-3-O-β-D-glucopyranoside (SG) were isolated from Pseuderanthemum palatiferum leaf extract which is used traditionally as an antidiabetic. ST and SG at doses of 0.25 and 0.50 mg/kg were fed to diabetic rats for 21 days, and the fasting blood glucose (FBG) level and biochemical data on day 0, 4, 7, 10, 14, 17 and 21 were determined and compared with the anti-diabetic drug, glibenclamine. FBG levels at all doses of ST and SG were significantly decreased (p<0.05) with a concomitant increase in serum insulin. SG at the dose of 0.50 mg/kg showed the highest hypoglycemic effect. ST and SG also improved the following biochemical data and hematology parameters such as total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein (LDL), blood urea nitrogen, creatinine, red blood cells, platelet and white blood cells. Key words: Pseuderanthemum palatiferum, acanthaceae, stigmasterol, sitosterol-3-O-β-D-glucopyranoside;, hypoglycemic activity.
Highlights
Pseuderanthemum palatiferum (Nees) Radlk is a medicinal plant belonging to the acanthaceae family
Some pharmacological properties of P. palatiferum have been reported to support the efficacy of its traditional use
Compound 1 was obtained as white needle crystals, mp 135 to 136°C and its molecular formula was assigned to be C29H48O according to it mass spectrum (m/z 412 [M]+)
Summary
Pseuderanthemum palatiferum (Nees) Radlk is a medicinal plant belonging to the acanthaceae family. The leaves of this plant are widely use in folk medicine of Vietnam and Thailand for promoting and treating of various diseases including hypertension, diarrhea, arthritis, hemorrhoids, stomach ache, tumors, colitis, bleeding, wounds, constipation, flu, colon cancer, nephritis and diabetes (Padee et al, 2010). Some pharmacological properties of P. palatiferum have been reported to support the efficacy of its traditional use. The leaf extract showed high antioxidant activity against the hydrogen peroxide radical in the
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