Abstract
To investigate the effects of whole grains(WG) and refined grains(RG) on blood glucose, blood lipid and inflammatory factors in normal rats, and the common effects of different whole grains. 2×2 factorial experiments were designed according to grain sources(rice & wheat) and processing precision(whole grain & refined grain). According to the initial body weight and fasting blood glucose, 48 male SD rats were randomly divided into four groups: RG rice group, WG rice group, RG wheat group and WG wheat group. They were fed with 45% refined rice, whole grain rice, refined wheat and whole grain wheat respectively for 18 weeks. The formula was in accordance with AIN-93 G. Food intake and body weight were monitored weekly. Fasting blood glucose, lipid, inflammatory factors and organ pathology were detected at the end of the experiment. During the experiment, the body weight growth and food intake of rats in each group were basically the same. At the end of the experiment, fatty liver appeared in varying degrees, while the kidney of rats in RG rice group and RG wheat group showed epithelial steatosis. Biochemical indexes showed that blood urea nitrogen(UN), fasting blood glucose(FBG), total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL)and monocyte chemoattractant protein-1(MCP-1)in RG wheat group were significantly higher than those in WG wheat group(P<0. 05), while high density lipoprotein(HDL)level in RG wheat group was significantly lower than that in WG wheat group(P<0. 05), and there was no significant difference in other indexes. The result of factorial analysis showed that the differences of FBG, serum insulin, homeostasis model assessment of insulin resistance(HOMA-IR)and C-reactive protein(CRP)caused by different grain processing degree were significant, but there was no significant difference between rice and wheat varieties(P>0. 05). Studies have shown that long-term feeding of refined grains can lead to fasting blood glucose, blood lipid abnormality and renal pathological changes in rats, and proper feeding of whole grains can delay the development of adverse symptoms.
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