Abstract
Periodontal Disease also called as Periodontitis is a chronic inflammatory disease in which there is destruction of tooth supporting structures. Bacterial infection is the main etiologic factor. The Bacterial agents stimulate a cascade of local inflammatory reactions including activation of immune system which in turn leads to activation and release of pro-inflammatory cytokines apart from activation of phagocytes and lymphocytes. The tissue destruction which occurs is believed to a consequence of host response to various bacterial agents. In the present review we summarize the role of cytokine Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) and Osteoprotegerin (OPG) in periodontal bone destruction during periodontitis.
Published Version
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