Abstract
English
Highlights
Copper (Cu) is an essential trace element found in small amounts in a variety of cells and tissues with the highest concentrations in the liver (Turnlund, 1998)
In our previous study (Ajuwon et al, 2009), we have demonstrated that dietary copper supplementation (250 mg/kg diet) induces oxidative damage by increasing lipid peroxidation and reducing concentration of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) in both erythrocyte and the liver of broiler chickens
Vitamin C supplementation for two weeks resulted to a significant reduction (p < 0.05) in lipid peroxidation in both tissues, which amounted to 48% in the erythrocyte and 52% in the liver (Tables 2 and 3)
Summary
Copper (Cu) is an essential trace element found in small amounts in a variety of cells and tissues with the highest concentrations in the liver (Turnlund, 1998) It functions as a cofactor and is required for structural and catalytic properties of a variety of important enzymes, including cytochrome c oxidase, tyrosinase, p- hydroxyl phenyl pyruvate hydrolase, dopamine beta hydroxylase, lysyl oxidase and Cu-Zn superoxide dismutase (Cu, Zn-SOD) (Gaetke and Chow, 2003; Turnlund, 1999; Uauy et al, 1998). Depletion of glutathione from cellular pool (either as a result of a disease condition or an experimental administration of thiol inhibitors), has been shown to render cells and living
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