Abstract
The dislipidemias are a risk factor well recognized of the cardiovascular diseases and constitute a problem of public health. A descriptive study in 150 patient elders of 30 years with diagnosis of Izquemic Cardiopathyes accomplished itself for the sake of identifying dislipidem- ias in patients of high cardiovascular risk that they helped the high-technology General Medical Center state James Marino Aragua, at the Republic Bolivariana of Venezuela, that you constituted the sign of study from October 2011 to October 2012. They used quantitative and qualitative variables like weight, age, sex, pathological personal background, risk factors cardiovascular associates, seric levels of total cho- lesterol, triglycerides, HDL cholesterol, LDL cholesterol VLDL cholesterol. 63 percent of patients with dislipidemias were detected, being hypercholesterolemia the more alteration frequently found. The ages understood between 41 and 60 years evidenced the bigger frequency.
Highlights
Cardiovascular diseases are one of the leading causes of death for people in developed countries world-wide
In the present study the effects of treatment with the antihypertensive drugs amlodipine, atenolol and captopril on alkaline phosphatase (ALP) activity and genomic DNA was investigated in liver, spleen and kidney of mice
After chronic administration of captopril and amlodipine, the activity of ALP in liver, spleen and kidney homogenates were highly significantly increased compared to its level in the organs of the control mice
Summary
Cardiovascular diseases are one of the leading causes of death for people in developed countries world-wide. Hypertension and osteoporosis are frequent diseases among elders. Both are induced by interaction of many genetic and environmental factors [1]. The depression in antioxidant enzymes and increase in oxidants in the hypertensive state have been reported to increase the production of reactive oxygen species [3,4]. The reactive oxygen species/free radicals resulting from the oxidantantioxidant imbalance tend to accumulate and are known to cause oxidative damage to the cellular macromolecules including the genetic material [5]. Captopril is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first ACE inhibitor developed and was considered a break through both because of its novel mechanism of action and because of the revolutionary development process [12]
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