Abstract
The present study was undertaken with a view to identify the role of the anti-fibroblastic activity of Mitomycin C IN preventing scarring at the osteotomy site in endoscopic dacryocystorhinostomy. A common cause of failure in DCR surgery is the closure of the osteotomy with soft tissue obstruction at the common canaliculus. If an antiproliferative agent such as MMC and 5-florouracil are applied at this area, it may reduce fibrosis to give a better result. For this study, patients coming to our OPD with complaints of chronic dacryocystitis, epiphora, and discharge from eye due to nasolacrimal duct blockage were selected. They underwent endoscopic DCR. For this randomized study, the patients were divided into 2 groups; • The control group • Those who underwent surgery with local application of MMC Patients underwent post -operative examination for complications like haemorrhage, wound infections, crusting, synechia & granulations. It was observed that the control group (without application of MMC) had more complications than the MMC group. The periods of observations were 1 week, 3 weeks and 3 months respectively. The patency of the duct was found to be more in MMC group than in control group. Duct patency was judged by clear flow of saline into the nasal cavity on syringing. Thus, it was concluded that, the adjunctive use of a wound healing inhibitor is considered to increased success rate of endoscopic, endonasal DCR.
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