Abstract
Four water-soluble polysaccharides (DNP1-1, DNP2-1, DNP3-1 and DNP4-2) were obtained from the aqueous extracts of the stems of Dendrobium nobile Lindl. by hot water extraction, ethanol precipitation, and fractionated by DEAE-cellulose ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The evaluation of tumor inhibition and immunomodulatory activity suggested that DNP4-2 could significantly increase the immune index, and strongly promote the secretion of IL-2, TNF-α and IFN-γ, and also decrease the concentrations of MDA in blood serum. DNP4-2 should be explored as a potential anti-tumor drug. Key words: Dendrobium nobile Lindl., immune stimulating, polysaccharide.
Highlights
Dendrobium nobile Lindl. (Chinese name “Jin Chai Shi Hu”) is one of the most famous Dendrobium plants in traditional Chinese medicine, it belongs to Orchidaceae, is a precious herbal plant in Chinese traditional medicine as a therapeutic for nourishing the stomach, promote secretion of saliva, and reduce fever (Shu et al, 2004), and it is one of the five species which were specified in the Chinese Phamacopeia (2005)
The aim of present study is to evaluate the mechanism of antitumor activities and immunomodulation effects of four polysaccharide fractions from D. nobile Lindl in vivo
The results suggested that these polysaccharides fractions from D. nobile Lindl. could not increasing the superoxide dismutase (SOD) activities in S180 mice
Summary
Dendrobium nobile Lindl. (Chinese name “Jin Chai Shi Hu”) is one of the most famous Dendrobium plants in traditional Chinese medicine, it belongs to Orchidaceae, is a precious herbal plant in Chinese traditional medicine as a therapeutic for nourishing the stomach, promote secretion of saliva, and reduce fever (Shu et al, 2004), and it is one of the five species which were specified in the Chinese Phamacopeia (2005). Plant polysaccharides are ideal candidates for therapeutics with immunomodulatory and antitumor effects and low toxicity (Schepetkin et al, 2006). Polysaccharides from some Dendrobium species exhibited high immunomodulatory and antitumor activities, such as Dendrobium huoshanense (Zha et al, 2007; Yves et al, 2008) and Dendrobium denneanum (Fan et al, 2010, 2011). Has strong anti-tumor activities (Wang et al, 2010), the mechanism of antitumor activity and immunomodulation effect of polysaccharides from D. nobile Lindl. The aim of present study is to evaluate the mechanism of antitumor activities and immunomodulation effects of four polysaccharide fractions from D. nobile Lindl in vivo
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
