Abstract
AbstractThrough systematic variations of the length of oligo(ethylene glycol)‐based linkers and the catalyst density of poly(styrene)‐supported cobalt‐salen catalysts, we have elucidated an optimal catalyst flexibility and density of polymeric Co‐salen catalysts for the hydrolytic kinetic resolution (HKR) of racemic terminal epoxides that follows a bimetallic cooperative pathway. The optimized polymeric catalyst brings the two cooperative Co‐salen units to a favorable proximity efficiently and hence displays significantly improved catalytic performance in the HKR compared with its monomeric small molecule analogue. Complex Co(5b), representing the most active poly(styrene)‐supported HKR catalyst known so far, can effect the resolution of a variety of epoxides to reach ≥98 % ee in 6–24 h with a low cobalt loading of 0.01–0.1 mol %.
Published Version
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