Engineered Tissue Graft for Repair of Injured Infraspinatus Rotator Cuff Tendon.

Abstract

Rotator cuff tears constitute a vast majority of shoulder related injuries, occurring in a wide population range and increasing in incidence with age. Current treatments for full thickness tears use suture to secure the ruptured tendon back to its native attachment site and often re-tear due to improper enthesis regeneration. To reduce the occurrence of re-tear, our lab developed an Engineered Tissue Graft for Rotator Cuff Repair (ETG-RC) to serve as an underlayment to traditional suture repair. We hypothesize the ETG-RC will aid in the repair of the torn rotator cuff tendon by promoting the regeneration of a functional enthesis. This devitalized graft fabricated from ovine derived bone marrow stromal cells was evaluated for biomechanical and histomorphology properties in an ovine infraspinatus rotator cuff repair model. Compared to a current standard practice Suture-Only model, the ETG-RC repair showed comparable high strain-to-failure forces, greater fibrocartilage deposition, regeneration of zonal gradients, and Shapey's fibers formation, indicative of enthesis regeneration. Enthesis regeneration following rotator cuff repair should repair mechanical properties and alleviate the need for subsequent surgeries required due to re-tear. The ETG-RC could potentially be used for repairing other tendon injuries throughout the body.