Engaging a polylactide copolymer in oral tissue regeneration: first validation of Suprathel® for guided epithelial and osseous healing.

Sergiu Văcăraş ,Cristian Dinu,Ileana Mitre,Septimiu Toader,Simion Bran,Dan Gheban,Gabriel Armencea,Avram Manea,Horațiu Alexandru Colosi ,Grigore Băciuţ ,Mihaela Hedeșiu ,Daiana Opriș ,W Kretschmer ,Mihaela Băciuț ,Horia Opriș

doi:10.25122/jml-2021-0083

Sergiu Văcăraş , Cristian Dinu + Show 13 more

Open Access

https://doi.org/10.25122/jml-2021-0083

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Abstract

The present study investigated the capacity of Suprathel® (a copolymer membrane, so far validated for skin regeneration) to also regenerate oral tissue – mucosa and bone, by comparing this biomaterial, in a split-mouth rabbit model, to Mucoderm®, a xenogeneic collagen matrix certified for keratinized oral mucosa healing. The clinical reason behind this experimental animal model was to determine whether the benefits of this advanced skin regeneration product (Suprathel®) could be conveyed for future evaluation in clinical trials of oral tissue regeneration in humans. The outcomes of this study validated the use of Suprathel®, a terpolymer of polylactide with trimethylene carbonate and ε-caprolactone, for stimulation of oral epithelium and alveolar bone regeneration in rabbits. Both Suprathel® and Mucoderm® exhibited comparable results and the null hypothesis stating a comparable regenerating effect of these two materials could not be rejected.

Highlights

Oral tissue regeneration is a sophisticated blend of intricated processes occurring continuously due to age, pathologic deterioration of gingiva and bone, trauma, and teeth loss
The study aimed to evaluate both epithelial and bone regeneration. It was structured based on two experimental arms that were created and followed in all 20 rabbits, using a split-mouth pattern according to a blinding protocol designed to compare epithelial and bone regeneration of the two investigated materials
One rabbit died on the 9th postoperative day, and no relation could be found with the experiment

Summary

Introduction

Oral tissue regeneration is a sophisticated blend of intricated processes occurring continuously due to age, pathologic deterioration of gingiva and bone, trauma, and teeth loss. Teeth loss is a process that determines resorption of the alveolar bone, which is clinically and radiologically evident by the loss of bone height and width [1]. The prosthetically-driven planning involves the correct three-dimensional (3D) positioning of dental implants, representing the key to therapeutic success [3]. Bone resorption occurs in time, but most of the bone is lost during the first 4 weeks after the tooth is lost, averaging 3–5 mm in width after 6 months [4]. Bone regeneration and other surgical augmentation procedures have been used with a high degree of success to restore the alveolar process and prepare the tissues for dental implant therapy with correct 3D positioning [5]. Socket preservation procedures have long been studied and implemented, but a consensus regarding the best method of preserving the bundle bone, using various types of bone substitute material, with or without barrier membranes, is still lacking [5, 7]

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