Abstract
Alzheimer's disease (AD) is the most common cause of dementia. Except for rare autosomal dominant hereditary forms, its etiology is unknown although some factors that facilitate their development has been decribed. The amyloid cascade remains its most backed etiopathogenic theory. Based on this hypothesis biomarkers has been developed to enable the advancement of the diagmosis to the early stages of the disease. This has led to a conceptual review EA that is no longer considered a type of dementia but a clinical-biological independent entity beginning in an asymotomatic phase and ending in severe dementia within 20-30 years time. Different forms of presentation, typical and atypical, each with characteristic clinical manifestations are described. The differential diagnosis includes other processes that course with cognitive impairment and other dementias both neurodegenerative and symptomatic
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