Abstract
Processes in submitochondrial vesicles obtained from the liver mitochondria of hypothyroid rats were compared at 25–30° with those from normal rats. Hypothyroidism did not alter the rates of oxidation of succinate or β-hydroxybutyrate, or energy-independent transhydrogenation of pyridine nucleotides. Energy-dependent transhydrogenation supported either by added ATP or by succinate oxidation was doubled in the vesicles of hypothyroid rats, whereas ATP-supported reversed electron-flow was unchanged. Hormone injection corrected the abnormal rate. Since submitochondrial vesicles phosphorylate ADP slowly at 30° in hypothyroidism (5), these data suggest that the thyroid state controls the use rather than the supply of available energy potential.
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