Abstract
1. 1. The effect of the thyroid on the conversion of carotene to vitamin A has been studied by determining the blood serum vitamin A levels in vitamin A-deficient rats, fed with and without thiouracil, after the oral or parenteral administration of carotene dispersed in water. 2. 2. No significant differences were found in the blood serum vitamin A levels of hypothyroid or normal rats 6 or 12 hr. after giving 200 μg. of carotene orally. With the same dosage intramuscularly, small, but similar, amounts of vitamin A appeared in the serums of both normal and hypothyroid rats. 3. 3. After five weekly oral doses of 200 μg. carotene, the livers of the hypothyroid rats contained as much vitamin A as did the livers of the normal rats. 4. 4. Animals given carotene either orally or intramuscularly had appreciable stores of vitamin A in their kidneys. There was no significant difference between the normal and thiouracil-treated rats.
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