Abstract
ABSTRACT Introduction: Many nervous system tissues and cells suffers positive changes when faced to exercise training. However, data on vagus nerve adaptation from exercise-induced study is absent. Objective: To analyze the effect of an endurance training on the vagus nerve morphology of rats. Methods: Wistar rats (6 months of age) were divided into two groups: control group (CG, n=8), and aerobic trained group (AT, n=8). AT was submitted to a treadmill training program of five times per week during 12 weeks. The maximum speed stipulated in the training protocol corresponded to 60% of the mean maximum intensity achieved by the group in the test of maximum effort. Results: Twelve weeks of treadmill training resulted in left ventricular hypertrophy in the AT group com-pared to CG. There was a significant increase in the area of both the myelinated and unmyelinated axons, and in the area of myelin sheath with training. The number of neurotubules and neurofilaments in myelinated fibers of aerobic trained group was significantly greater than CG (p≤0.05). Conclusion: Endurance training promoted significant increase in morphometric parameters of the vagus nerve in the same way it affect somatic nerves.
Highlights
Many nervous system tissues and cells suffers positive changes when faced to exercise training
Rats were randomly divided into two groups: control group (CG) (n=8) and aerobic trained group (AT) (n= 8), both sacrificed with 9 months of age
No significant difference was observed in the body weight and left ventricle (LV) wall thickness between the CG and AT groups
Summary
Many nervous system tissues and cells suffers positive changes when faced to exercise training. There was a significant increase in the area of both the myelinated and unmyelinated axons, and in the area of myelin sheath with training. The vagus nerve is one of the most important visceral nerve[9,10,11] controlling the function of thoracic and abdominal viscera and maintaining homeostasis under changing environmental and behavioral conditions.[11,12,13,14] It contains afferent and efferent myelinated and unmyelinated axons, involved in vital reflexes such as cardiovascular, pulmonary and gastrointestinal input to and from the central nervous system.[15,16,17] It contains a number of collagen fibers in the interstitial space among nerve fibers.[18]
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