Abstract
BackgroundResearches have revealed that the endothelial nitric oxide synthase (eNOS) gene G894T polymorphism is associated with the risk of Myocardial infarction (MI), but the results remain conflicting.Objective and MethodsA meta-analysis was conducted to investigate the association between eNOS G894T polymorphism and MI. Published studies from PubMed, Embase, CNKI and CBM databases were retrieved. The pooled odds ratios (ORs) for the association between eNOS G894T polymorphism and MI and their corresponding 95% confidence intervals (CIs) were estimated using the random- or fixed- effect model.ResultsA total of 34 studies including 8229 cases and 12839 controls were identified for the meta-analysis. The eNOS G894T polymorphism was significantly associated with MI under a homozygous genetic model (OR = 1.41, 95% CI = 1.08–1.84; P = 0.012), a recessive genetic model (OR = 1.35, 95% CI = 1.06–1.70; P = 0.014), a dominant genetic model (OR = 1.18, 95% CI = 1.04–1.34; P = 0.009). In the subgroup analysis by ethnicity (non-Asian and Asian), no significant association was observed between eNOS G894T polymorphism and MI risk among non-Asians (P>0.05), but a positive significant association was found among Asians (P<0.05).ConclusionsThe eNOS G894T polymorphism is associated with increased MI risk in Asians. The results indicate that ethnicity plays important roles in the association between eNOS G894T polymorphism and MI.
Highlights
Myocardial infarction (MI) is a complex syndrome determined by multiple predisposing genetic and environmental factors.Previous studies have investigated the association of genetic variants in DNA repair pathways, lipid-related pathways, fibrinolytic system, renin angiotensin aldosterone system and nitric oxide synthase with MI risk [1,2,3,4,5].There are several forms of nitric oxide synthase such as neuronal nitric oxide synthase, endothelial nitric oxide synthase, inducible nitric oxide synthase
In the subgroup analysis by ethnicity, no significant association was observed between endothelial nitric oxide synthase (eNOS) G894T polymorphism and MI risk among non-Asians (P.0.05), but a positive significant association was found among Asians (P,0.05)
The eNOS G894T polymorphism is associated with increased MI risk in Asians
Summary
Myocardial infarction (MI) is a complex syndrome determined by multiple predisposing genetic and environmental factors.Previous studies have investigated the association of genetic variants in DNA repair pathways, lipid-related pathways, fibrinolytic system, renin angiotensin aldosterone system and nitric oxide synthase with MI risk [1,2,3,4,5].There are several forms of nitric oxide synthase such as neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS). Myocardial infarction (MI) is a complex syndrome determined by multiple predisposing genetic and environmental factors. Previous studies have investigated the association of genetic variants in DNA repair pathways, lipid-related pathways, fibrinolytic system, renin angiotensin aldosterone system and nitric oxide synthase with MI risk [1,2,3,4,5]. The vascular nitric oxide (NO), mainly produced by eNOS, is a critical molecule in regulating the vascular system, including the inhibition of the platelet aggregation and adhesion and reduction of vascular smooth muscle cell proliferation [6]. NO regulation may result from the functional eNOS genetic polymorphisms. Researches have revealed that the endothelial nitric oxide synthase (eNOS) gene G894T polymorphism is associated with the risk of Myocardial infarction (MI), but the results remain conflicting
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