An association between the endothelial nitric oxide synthase gene G894T polymorphism and premature coronary artery disease: a meta-analysis.

Boqian Zhu,Jiantong Hou,Chengchun Tang,Yong Qiao,Dong Wang,Yaoyao Gong,Xinmin Si,Gaoliang Yan,Bo Liu

doi:10.18632/oncotarget.20400

Boqian Zhu, Jiantong Hou + Show 7 more

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https://doi.org/10.18632/oncotarget.20400

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Abstract

Previous epidemiological studies have suggested that genetic factors are more likely to influence the development of premature coronary artery disease (CAD) than disease in older patients. Several studies have evaluated the association between the G894T polymorphism located in an exon of endothelial nitric oxide synthase (eNOS) and the risk of premature CAD. However, the findings were inconsistent. Thus, we performed a meta-analysis to clarify the association; we conducted both overall and subgroup analyses. Odds ratios and 95% confidence interval were calculated to evaluate the association between the G894T polymorphism and the risk of premature CAD. Overall analysis revealed a significant association. Subgroup analysis in terms of ethnicity revealed a significant association, in all models evaluated, between the G894T polymorphism and susceptibility to premature CAD in mixed population. In contrast, no such association was evident in Caucasians and Asians. On further subgroup analysis based on the premature CAD subtypes, we found that the G894T polymorphism was correlated with premature myocardial infarction (MI) but not with premature CAD without MI. In conclusion, we confirmed that the eNOS G894T polymorphism is a risk factor for premature CAD, particularly in those suffering premature MI.

Highlights

Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide [1]
On further subgroup analysis based on the premature coronary artery disease (CAD) subtypes, we found that the G894T polymorphism was correlated with premature myocardial infarction (MI) but not with premature CAD without MI
We found a significant association between the G894T polymorphism and premature CAD in the allelic (OR = 1.31, 95% confidence intervals (CIs) 1.01–1.71; P = 0.045) and recessive (OR = 1.67, 95% CI 1.08–2.58; P = 0.022) models, but not in the dominant model (OR = 1.28, 95% CI 0.97–1.69; P = 0.09)

Summary

Introduction

Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality worldwide [1]. Diabetes mellitus, hypertension, hyperlipidemia, obesity, and smoking are major risk factors for CAD [2]. Premature CAD, defined as CAD developing in males aged < 55 years and females aged < 65 years, has become more prevalent in recent years, in developing countries [3]. Genetic factors seem to play a prominent role in the development of premature CAD [4]. Earlier epidemiological data suggested that such genetic factors were more likely to affect younger than older subjects [3]. Premature CAD is generally associated with a low atherosclerotic burden in the coronary arteries and a family history of CAD [5,6]

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