Abstract
Goals: The aim of the study was to evaluate endoscopic yield in patients with Anemia of Chronic Disease (ACD) who had no Gastrointestinal (GI) symptoms. We analyzed the impact of laboratory and clinical variables on endoscopic yield in this cohort.
Highlights
Anemia is broadly defined as abnormally low Hemoglobin (Hb), with an Hb of ≤ mg/dl in women and ≤ mg/dl in men [1,2,3]
Our study suggests that EGD may be beneficial for evaluation of all patients with Anemia of Chronic Disease (ACD) without GI symptoms, regardless of underlying lab or clinical findings
Due to limited yield of colonoscopy in patients with ACD, colonoscopy should be performed on a case-by-case basis
Summary
Anemia is broadly defined as abnormally low Hemoglobin (Hb), with an Hb of ≤ mg/dl in women and ≤ mg/dl in men [1,2,3]. The two most common causes of chronic anemia in the world are Iron Deficiency Anemia (IDA) and Anemia of Chronic Disease (ACD) [25]. Concomitant IDA and ACD may be present and better characterized as a Mixed Anemia (MA). A serum ferritin of >100 ng/ ml makes a diagnosis of iron deficiency unlikely and suggestive of ACD [8,10,11]. Iron Deficiency Anemia (IDA) is a known indication for endoscopy to rule out GI source of blood loss. We categorized patients into IDA, ACD, or Mixed Anemia (MA) based on serum ferritin levels of ≤ 30 ng/ml, 30-100 ng/ml, and >100 ng/ml, respectively, and evaluated endoscopic yield and clinical variables
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