Abstract
Aims: In order to investigate the preventive effect of endoscopic nasobiliary drainage (ENBD) on the postoperative complications of ERCP with endoscopic sphincterotomy (EST) for choledocholith. Methods: we collected 180 patients with choledocholith who received the treatment of ERCP for extracting stones between January 2007 and June 2009. All of the 180 patients were divided into two groups: the ENBD group which, including 80 patients, were placed with ENBD, and the control group, including the residual 100 patients, were not placed with ENBD. We measured the scrum amylase levels within 24 hours, before and after ERCP. Meanwhile, the incidences of hyperamylasemia, acute pancreatitis, cholangitis and sphincter of Oddi dysfunction (SOD) were observed after ERCP. Results: The ENBD group shown lower scrum amylase levels after ERCP (225.78±178.62 vs. 563.08±201.24, P 0.05) before ERCP. At the same time, ENBD group were found with less incidences of hyperamylasemia (5% vs. 18%, P 0.05) than control group. Conclusion: Out results suggested that ENBD can prevent the complications of hyperamylasemia, acute pancreatitis and SOD after ERCP effectively.
Highlights
With the development of ERCP technology, therapeutic ERCP has played an important pole in the treatment of biliary and pancreatic diseases
The mean serum amylase was lower in the endoscopic nasobiliary drainage (ENBD) group versus in the control group and the difference was statistically significant after ERCP (P
The incidence of hyperamylasemia was higher in the ENBD group versus in the control group (5% vs. 18%, P
Summary
With the development of ERCP technology, therapeutic ERCP has played an important pole in the treatment of biliary and pancreatic diseases. The treatment of ERCP with endoscopic sphincterotomy (EST) has a high achievement in curing choledocholith, but it can bring out a series of complications such as hyperamylasemia, acute pancreatitis, hemorrhage and perforation. It is valuable to investigate the measures to prevent postoperative complications of ERCP for choledocholith. Some researcher had reported that ENBD was a certain preventive effect on postoperative complications, whether ENBD performed after therapeutic ERCP has not been concluded [1,2,3]. We had retrospectively analyzed the condition of complications after ERCP for extracting stones, and compared the incidence of complications in cases when naso-biliary tube procedure was performed with in cases was not. To comprehend whether postoperative complications of ERCP for extracting stones are prevented or reduced by ENBD performed
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