Abstract
Recent investigations have revealed a concerning association between the administration of the third dose of the ModRNA COVID-19 vaccine and statistically significant increases in cancer mortality rates. A study conducted in Japan highlighted this correlation, noting a marked rise in cancer-related deaths post-vaccination. This phenomenon is not isolated to Japan; similar trends have been observed in Europe, Australia, and the USA, with an excess of deaths reported from 2020 to 2023 compared to 2019. In this review, we explore seven potential mechanisms through which ModRNA COVID-19 vaccines may contribute to the initiation and progression of cancer. Each mechanism is discussed in detail, with a focus on the underlying molecular and cellular pathways. The potential for varied combinations of these mechanisms to influence different cancer types is also considered, providing a comprehensive overview of how ModRNA vaccines might impact cancer biology. Our analysis underscores the necessity for further research to elucidate the precise relationship between ModRNA COVID-19 vaccination and cancer progression. Understanding these mechanisms is critical for developing strategies to mitigate potential adverse effects while harnessing the benefits of vaccination.
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